Consistently

patrick wilson和他的同事们发现,尽管人体内受葡萄球菌感染的循环抗体有能力识别广泛的细菌蛋白,但是活跃的免疫应答是专注于蛋白a(spa)

1.pauli, n.t., et al. .

doi:10.1084/jem.

目前尚不清楚为什么抗体抵抗spa而不保护spa,但这些数据表明未来疫苗的设计方法必须要避开细菌的干扰(生物谷 bioon.com)

抗体生产b细胞在其表面表达高变量受体,但通常情况下只有少数b细胞能够识别特定分子(抗原),也就是经常入侵病原体的那一部分抗原当一个b细胞遇到它的特异性抗原时,那么它的表面受体会更好、更快的识别第二次特异性抗原但当spa作为一个“超级抗原”就意味着它激活了许多b细胞而不管肺炎球菌感染首选它们的受体是否具有特异性一旦b细胞被激活,那么受葡萄球菌感染的人体中的b细胞会调整它们的受体去识别spa而不是它们的目的抗原这可能是病菌克制了b细胞,否则它不会为其它的细菌组成部分产生特异保护性抗体

金黄色葡萄球菌通过医院血液感染获得几率大约占20%,而且耐药菌株(mrsa)也在不断增多不幸的是,通过接种疫苗保护人们免受金黄色葡萄球菌的感染非常失败小鼠研究表明抵抗金黄色葡萄球菌感染依赖于抗体的产生尽管一些细菌的蛋白质可以被人类抗体识别,但是这些抗体往往不足以抵御细菌感染或防止人体再次被感染

2014年10月29日 讯 /生物谷bioon/ --近日研究发现,潜在的致命细菌可以逃避免疫监视来保护自身安全,芝加哥大学科学家的一金葡萄球菌感染症状项相关研究发表在《实验医学杂志》上

staphylococcus aureus infection induces protein a–mediated immune evasion in humans.

pmid:

pmc:

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staphylococcus aureus bacterial infection commonly results in chronic or recurrent disease, suggesting that humoral memory responses are hampered. understandi金葡萄球菌感染症状ng how s. aureus subverts the immune response is critical for the rescue of host natural humoral immunity and vaccine development. s. aureus expresses the virulence factor protein a (spa) on all clinical isolates, and spa has been shown in mice to expand and ablate variable heavy 3 (vh3) idiotype b cells.葡萄球菌感染 the effects of spa during natural infection, however, have not been addressed. acutely activated b cells, or plasmablasts (pbs), were analyzed to dissect the ongoing immune response to infection through the production of monoclonal antibodies (mabs). the b cells that were activated by infection had a h表皮葡萄球菌感染ighly limited response. when screened against multiple s. aureus antigens, only high-affinity binding to spa was observed. consistently, pbs underwent affinity maturation, but their b cell receptors demonstrated significant bias toward the vh3 idiotype. these data suggest that the superantigenic acti金葡萄球菌感染肺炎vity of spa leads to immunodominance, limiting host responses to other s. aureus virulence factors that would be necessary for protection and memory formation.

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